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Journal Article 5

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HLA/RTI 2

Alloimmunity 1

Autoimmunity 1

Bioengineering 1

Chimeric antigen receptors 1

DQB1 1

IgA nephropathy 1

SOAP 1

T cell 1

Transplant 1

Treg 1

agent 1

alloantibody 1

antibody mediated rejection 1

architecture 1

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complex systems 1

computer simulation 1

distributed simulation 1

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Research of HLA distributed simulation extension

Wu Zebin,Wu Huizhong,Li Weiqing

Strategic Study of CAE 2008, Volume 10, Issue 7, Pages 141-146

Abstract:

Studying on related work about HLA extension, two typical problems ofHLA distributed simulation interoperability and reusability are focused on, and a decoupled architectureof HLA extension is proposed based on web services.Encapsulation and deployment of RTI services, as well as a remapping of the RTI API calls to SOAP isThe extension can encapsulate intrinsic RTI library and extend traditional HLA distributed simulation

Keywords： HLA/RTI distributed simulation web services SOAP architecture

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Design and Research of Computer Simulation for Complex System

Jin Shiyao,Li Hongliang,Dang gang,Wang Zhaofu,Liu Xiaojian

Strategic Study of CAE 2002, Volume 4, Issue 4, Pages 52-57

Abstract:

The complex systems and complexity is the kernel scientific problem of the 21st century. Due to the complexity and indetermination of complex systems, it is difficult to study the complex systems with the traditional reductive theory. The agent-based fuzzy computer simulation is approved in the paper, and a distributed simulation platform based on the agents is designed.

Keywords： complex systems computer simulation agent HLA/RTI

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HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 298-313 doi: 10.1007/s11684-018-0636-x

Abstract: severely impeded by the production of alloantibodies, mainly directed against the protein products of the HLAThis review addresses the question of HLA matching in lung transplantation and current knowledge of theallogenicity of different HLA class I and II antigens.

Keywords： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 507-516 doi: 10.1007/s11684-016-0475-6

Abstract: Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLAThis study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibilityA PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects.High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients

Keywords： DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study

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Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3, Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract:

Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionized the field of adoptive cellular therapy (ACT). Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR construct. The advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology, and it is clear that such cells have greater accuracy, potency, and reduced off-target therapeutic effects compared with their unmodified counterparts. In contrast to conventional T cells (Tconvs), regulatory T cells (Tregs) play a major role in suppressing immune activation and regulating the host immune response. CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases, graft-versus-host disease (GvHD), and organ transplant rejection. In the latter, they hold immense potential as mediators of immune tolerance for recipients of allotransplants. However, current research into CAR-Treg engineering is extremely limited, and there is uncertainty regarding optimal design for therapeutic use. This review examines the rationale behind the development of CAR-Tregs, their significance for human transplantation, potential designs, safety considerations, and comparisons of CAR-Tregs in transplantation models to date.

Keywords： Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity